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by Jonathan Colledge
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Cervical cancer TNM staging (UICC/AJCC 7th edition)

Currently in beta testing stage. Manual verification of results is required.

T

If only seen microscopically:

If clinically visible:

N

M

TNM staging =

FIGO staging =

T1 tumours can be either visible only on microscopy or clinically visible. T1a tumours are only visible by microscopy and correspond to stromal invasion ≤ 3 mm (T1a1) or > 3 mm but ≤ 5 mm (T1a2). Where the horizontal spread of the tumour is more than 7 mm or the stromal invasion is deeper than 5 mm, the tumour is T1b. Clinically visible lesions are either T1b1 or T1b2 depending on whether the lesion is ≤ 4 cm (T1b1) or > 4 cm (T1b2).
T2 tumours extend beyond the uterus (e.g. the upper 2/3 of the vagina) and there are two subdivisions of T2a based on a size cut off of 4 cm (≤ 4 cm = T2a1 and > 4 cm = T2a2). T2b is not subdivided and occurs with parametrial invasion.
T3 tumours are subdivided into T3a (involving the lower 1/3 of the vagina) and T3b (involving the pelvic wall or lower ureter to cause hydronephrosis/non-functioning kidney).
T4 tumours involve bladder or bowel mucosa or extend beyond the pelvis.

The regional lymph nodes of cervix are defined in the AJCC Cancer Staging Manual(1) as:

Parametrial, obturator, internal iliac, external iliac, common iliac, sacral and presacral

The UICC(2) give an optional subclassification of nodal disease where N1a is 1-2 involved regional nodes inferior to the common iliac nodes, N1b is ≥ 3 involved regional nodes inferior to the common iliac nodes, and N1c is involvement of a common iliac node(s).

Also, an optional subclassification of metastatic disease is given where M1a is involvement of sub-diaphragmatic para-aortic lymph nodes with M1b representing the remainder.

FIGO staging

For N0 disease the FIGO staging corresponds to the T staging up to T3b. N1 disease gives a FIGO stage of IIIB. A T4 tumour gives stage IVA disease and metastases give IVB disease.

References

  1. AJCC Cancer Staging Manual. (Springer, 2011).
  2. C. Wittekind, TNM Supplement: A Commentary on Uniform Use, 4th Edition. Wiley-Blackwell, 2012.

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